3/9/2023 0 Comments Groupspro 3![]() ![]() The Intercept has published the apparent full list of the social network's "Dangerous Individuals and Organizations" (DIO) which they ban their users from discussing in order to combat violence on the platform. doi: 10.1093/brain/awn261.A secret list of people and organizations which Facebook considers "dangerous" contains several groups which reference former President Donald Trump in their name. Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain. doi: 10.1007/s0040-y.īoche D, Zotova E, Weller RO, Love S, Neal JW, Pickering RM, Wilkinson D, Holmes C, Nicoll JA. Reduction of aggregated tau in neuronal processes but not in the cell bodies after Abeta42 immunisation in Alzheimer's disease. Evaluation of the safety and immunogenicity of synthetic Abeta42 (AN1792) in patients with AD. doi: 10.1111/nan.12205.īayer AJ, Bullock R, Jones RW, Wilkinson D, Paterson KR, Jenkins L, Millais SB, Donoghue S. Effect of amyloid-beta (Abeta) immunization on hyperphosphorylated tau: a potential role for glycogen synthase kinase (GSK)-3beta. doi: 10.1369/jhc.6A7156.2007.Īmin J, Paquet C, Baker A, Asuni AA, Love S, Holmes C, Hugon J, Nicoll JA, Boche D. Actin-binding proteins coronin-1a and IBA-1 are effective microglial markers for immunohistochemistry. ![]() Aβ-immunisation promoted increased Iba1 and P2RY12 expression, likely reflecting increased baseline microglial motility but without restoring the profile observed in controls.Īlzheimer’s disease Aβ-immunotherapy Cell motility Human microglia Neuroinflammation.Īhmed Z, Shaw G, Sharma VP, Yang C, McGowan E, Dickson DW. Pro- and anti-inflammatory proteins were increased in AD, whereas immunotherapy appears to result in a slightly less pro-inflammatory environment.Our findings suggest that as Aβ appears during the ageing process, the homeostatic Iba1 and P2RY12 -positive microglia respond to Aβ, but this response is absent in AD. Iba1 and P2RY12 showed significant positive correlations with Aβ in controls but not in the AD or iAD groups. The expression of all four motility-related proteins was unmodified in AD compared with controls, whereas Iba1 and P2RY12, the homeostatic markers, were increased in the iAD group compared with AD. ![]() The neuroinflammatory environment was characterised using Meso Scale Discovery multiplex assays. Experimental evidence suggests impaired microglial motility in Alzheimer's disease (AD) and therefore we have investigated whether the expression of proteins associated with motility is altered in AD and affected by the Aβ immunotherapy using post-mortem brain tissue of 32 controls, 44 AD cases, and 16 AD cases from our unique group of patients immunised against Aβ42 (iAD).Sections of brain were immunolabelled and quantified for (i) the motility-related microglial proteins Iba1, cofilin 1 (CFL1), coronin-1a (CORO1A) and P2RY12, and (ii) pan-Aβ, Aβ42 and phosphorylated tau (ptau). ![]() Microglial function is highly dependent on cell motility, with baseline motility required for homeostatic surveillance activity and directed motility to migrate towards a source of injury. ![]()
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